Rajan Sah receives a new Research Grant from the American Diabetes Association.

Rajan Sah, M.D., Ph.D., Assistant Professor of Internal Medicine (Cardiology) and member of the Fraternal Order of Eagles Diabetes Research Center was recently awarded a Research Grant from the American Diabetes Association (ADA). The project entitled: SWELL1 regulation of ß-cell excitability and insulin secretion will be supported by the $345,000 award over the next three years. Dr. Sah’s laboratory discovered that a protein SWELL1 regulates the electrical activity on the surface membranes of pancreatic beta cells that is critical for insulin release. The studies will test the hypothesis that SWELL1-mediates a swell-activated excitatory chloride current that potentiates insulin release in response to physiological changes in extracellular glucose. Dr. Sah will conduct studies in cultured pancreatic beta cells and in mice in which the levels of SWELL1 in beta cells are manipulated. These studies of SWELL1 may provide a new pharmacological target for the treatment of diabetes, by complementing other groups of drugs such as sulfonylurea receptor inhibitors such as glipizide or glyburide, which are currently used in clinical practice. Congratulations to Dr. Sah for this outstanding achievement.

Sah, Rajan big

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