Abel Lab receives new $1.4M grant from the National Institutes of Health to study how mitochondrial proteins link estrogen to thrombosis risk.

Making the Rounds

E. Dale Abel, MD, PhD, has received a two-year, $1.4M NIH grant to explore potential links between estrogen, platelet mitochondria, and increased incidence of thrombosis in females, particularly following estrogen exposure. A successful outcome may identify novel biomarkers that might predict thrombosis risk in this susceptible population.

The mitochondrial protein, OPA1, plays an important role in mitochondrial fusion. Previous epidemiological studies had revealed increased OPA1 in platelets of women but not in men. Also, during pregnancy, increased OPA1 levels in platelets correlate with increased platelet activation. To better understand the molecular mechanisms for this association, Dr. Abel’s laboratory generated mice that lacked OPA1, specifically in platelets. Male OPA1-deficient platelets exhibited overt mitochondrial damage, which was not evident in females. Remarkably, reduced OPA1 in platelets increased the risk of thrombosis in males but decreased the risk of thrombosis in female animals. These phenotypes could be transferred when platelets from one sex were transferred into animals of the opposite sex.

The…

View original post 97 more words

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google+ photo

You are commenting using your Google+ account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s

%d bloggers like this:
search previous next tag category expand menu location phone mail time cart zoom edit close