Diabetes Research Center Member Long-Sheng Song’s study finds that stress changes a structural protein into a gene regulator that protects against heart failure

Dr. Long-Sheng Song has been focusing on a protein called junctophilin-2 (JP2). Previous work in Dr. Song’s lab revealed that JP2 is a structural protein that is essential for heartbeat and that loss or disruption of JP2 is associated with heart failure.

The new study posted in the journal Science finds that one of the newly created fragments of JP2 protects the heart from damage by traveling to the heart cells’ nuclei and turning off the expression of genes that promote heart failure.

“Our findings suggest that increasing the level of JP2 fragment or functional peptide in the heart might hold promise as a strategy for treating heart failure,” said Dr. Song.

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