DRC member Eric Taylor leads a study that suggests new metabolic target for liver cancer

Director of the FOEDRC Metabolomics Core Facility, Eric Taylor, PhD is the lead investigator in a new study that finds that disrupting a metabolic pathway in the liver in a way that creates a more “cancer-like” metabolism actually reduces tumor formation in a mouse model of liver cancer.

Because liver cancer is the fifth most common cancer worldwide and continues to rise, factors that cause it, such as obesity and diabetes are becoming more common. The results were surprising because disrupting the mitochondrial pyruvate carrier (MPC) promotes a more cancer-like metabolism, with cells increasing their use of glucose and an amino acid called glutamine to produce energy.

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