DRC member Matthew Potthoff and graduate student Sharon Jensen-Cody receive the cover of Molecular Metabolism for their recent review, “Hepatokines and metabolism: Deciphering communication from the liver”.
The review articulates the central role of the liver in metabolic cross talk. The liver is a key regulator of systemic energy homeostasis and can sense and respond to nutrient excess and deficiency through crosstalk with multiple tissues. The liver has also recently been recognized as an endocrine organ that secretes hepatokines, which are liver-derived factors that can signal to and communicate with distant tissues. In this review, we highlight key hepatokines and their role in metabolic control. We also examine the molecular mechanisms of each hepatokine and discuss their potential as therapeutic targets for metabolic disease.