Abel-led investigation shows high-fat or ketogenic diet prevents heart failure in mouse study

An Abel-led study shows how glucose byproducts contribute to worsening heart failure in mice, but is prevented by high-fat or ketogenic diets. The study, “Mitochondrial pyruvate carriers are required for myocardial stress adaption”, published October 26 ahead of the November issue of the journal Nature Metabolism, was one of three companion papers from independent research teams. They all point to the damaging effecrs of excess sugar and its breakdown products on the heart.

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